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Arbutin (C₁₂H₁₆O₇)

  • Product Name Alpha-Arbutin
  • CAS No 84380-01-8
  • MF C12H16O7
  • MW 272.251
  • Specification 99%
  • Test Method HPLC
  • Certificates HACCP, FSSC22000, Kosher, Halal, FDA, SGS
  • Shelf Time 2 years
  • Package 25kg/Drum

Description

Arbutin (C₁₂H₁₆O₇), chemically known as hydroquinone-β-D-glucopyranoside, is a naturally occurring glycosylated hydroquinone derivative. As a commercially significant skin-brightening agent, it is obtained through multiple production methods:

Arbutin-(C₁₂H₁₆O₇)-(4)

1. Plant Extraction (Primary Natural Source):
Derived from bearberry (Arctostaphylos uva-ursi) leaves (5-15% content)
Also extracted from pear tree bark, blueberry leaves, and wheat
Typical extraction yield: 3-8% of dry plant weight
Requires multi-step purification including macroporous resin chromatography

2. Enzymatic Synthesis:
β-Glucosidase-mediated glycosylation of hydroquinone
Yields >95% α- and β-arbutin mixture
Requires precise control of reaction conditions

3. Chemical Synthesis:
Koenigs-Knorr glycosylation of acetobromoglucose
Produces β-arbutin with ≥98% purity
Involves toxic reagents requiring complete removal

Molecular Characteristics

Molecular weight: 272.25 g/mol

Melting point: 195-198°C (decomposition)

Specific rotation: -64° (c=1 in water)

UV λmax: 282 nm (ε=1,600 M⁻¹cm⁻¹)

Physicochemical Properties

Solubility Profile:
Water: 50 g/L (20°C)
Ethanol: 10 g/L
Propylene glycol: 35 g/L
Insoluble in non-polar solvents

Stability Parameters:
pH stability: 3-7 (optimal 5.5-6.5)
Photostability: Degrades under UV exposure
Thermal stability: Decomposes above 200°C

Technical specifications (cosmetic grade)

Purity: ≥99% (HPLC)

α/β isomer ratio: <1:99 (for β-arbutin)

Heavy metals: ≤10 ppm

Residual solvents: ≤50 ppm

Microbial limits: ≤100 CFU/g

Benefits

1. Formulation Stability: Maintains efficacy in cosmetic matrices

2. Solubility Advantage: Water-soluble for aqueous systems

3. pH Compatibility: Stable in cosmetic pH ranges

4. Synergistic Potential: Combines well with other actives

Arbutin-(C₁₂H₁₆O₇)-(2)
Arbutin-(C₁₂H₁₆O₇)-(3)

Applications

1. Cosmetic Skin Care:
Brightening creams and serums
Age spot correction products
Post-inflammatory hyperpigmentation treatments

2. Pharmaceutical Preparations:
Topical depigmenting formulations
Combination therapies for melasma
Transdermal delivery systems

3. Functional Cosmeceuticals:
BB/CC creams with whitening effects
Sun protection aftercare products
Night repair treatments

4. Specialty Products:
Underarm whitening formulations
Intimate area lightening products
Scar appearance improvement creams

Product Processing

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Standard and Certificates 

All of our products are made in a GMP-compliant facility where every step of production is carefully managed. Over the years, our factory has passed several well-recognized audits, including HACCP, ISO22000 and ISO9001. The products also meet Kosher and Halal requirements, and we hold FDA registration as well. These certifications reflect the standards we follow rather than just labels we collect—they’re part of how we ensure consistency and safety in every batch. 


Free Sample Available 

If you’d like to get a feel for the product before placing an order, we can send you a free sample. In most cases, we provide around 10–20 grams so you can evaluate the quality yourself. For items with higher raw material costs, we will confirm the exact amount we can offer so everything is clear before shipping. 


Standard Packaging and Private Label 

For regular shipments, we usually pack goods in 1–5 kg aluminum foil bags, 10–20 kg cartons, or 10–30 kg fiber drums, depending on the item and order size. 
If you’re planning to sell under your own brand, we also handle private labeling. We can help design and produce packaging with your logo or artwork so the products arrive ready for retail. Many customers find this saves them a lot of time compared with printing and repacking on their end. 

Shipping Method 

Orders under one metric ton are generally shipped through major express couriers such as DHL, FedEx, UPS or EMS. For larger quantities, we can arrange transport by sea or railway. The best method depends on your location and how quickly you need the goods, so we’ll help you choose the most practical option. 


After Sale Services 

Most of our products remain stable for up to two years, and we guarantee their quality within that period. If anything arrives below your expectations, our return process is straightforward. You can send back the portion in question, and we will refund the corresponding amount—no complicated procedures or hidden conditions. 

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