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Berberine Hydrochloride (CAS 633-65-8)

Product Name Berberine Hydrochloride
CAS No 2086-83-1
MF C20H18NO4+
MW 336.366
Specification 99%
Test Method HPLC
Certificates HACCP, ISO22000, Kosher, Halal, FDA, SGS
Shelf Time 2 years
Package 25kg/Drum

product details

Product Description

Berberine Hydrochloride (CAS 633-65-8) is a bioactive isoquinoline alkaloid derived from plants such as Berberis vulgaris (barberry), Coptis chinensis (goldthread), and Hydrastis canadensis (goldenseal). It is widely recognized for its bright yellow color and bitter taste, commonly used in traditional Chinese and Ayurvedic medicine for centuries.

Berberine Hydrochloride is a naturally occurring quaternary ammonium salt isolated from medicinal plants including:

1. Berberis aristata (Indian barberry) - root bark contains 3-4% berberine

2. Coptis chinensis (Chinese goldthread) - rhizome yields 5-7% berberine

3. Hydrastis canadensis (Goldenseal) - root contains 2.5-4% berberine

Chemical Properties

Molecular Weight: 371.81 g/mol

Purity: Typically >95% (HPLC-tested)1

Solubility:
Soluble in hot water
Slightly soluble in ethanol
Insoluble in ether & chloroform4

Extraction & Standardization

Conventional solvent extraction (ethanol/water) at high temperatures.

Advanced methods (ultrasound-assisted, supercritical CO₂) improve yield and reduce chemical residues3.

HPLC-verified to ensure consistent alkaloid content.

Quality Specifications

Heavy metals:
Pb <0.1 ppm
As <0.05 ppm
Cd <0.02 ppm

Residual solvents:

Ethanol <500 ppm
Methanol <300 ppm

Microbiological:
TAMC <1000 CFU/g
Yeast/mold <100 CFU/g

Benefits

✔ Blood Sugar Support – Enhances insulin sensitivity.

✔ Heart Health – Lowers LDL & triglycerides.

✔ Antimicrobial – Fights bacteria & fungi.

✔ Anti-Inflammatory – Reduces chronic inflammation.

✔ Weight Management – Supports metabolic function.

Applications

Dietary Supplements: Capsules (500-1,500 mg/day).

Functional Foods: Added to diabetic-friendly products.

Pharmaceuticals: Investigated for anti-cancer & anti-diarrheal use5.

Cosmetics: Skin health formulations (antioxidant & anti-acne).

Product Processing

Standard and Certificates

All of our products are made in a GMP-compliant facility where every step of production is carefully managed. Over the years, our factory has passed several well-recognized audits, including HACCP, ISO22000 and ISO9001. The products also meet Kosher and Halal requirements, and we hold FDA registration as well. These certifications reflect the standards we follow rather than just labels we collect—they’re part of how we ensure consistency and safety in every batch.

Free Sample Available

If you’d like to get a feel for the product before placing an order, we can send you a free sample. In most cases, we provide around 10–20 grams so you can evaluate the quality yourself. For items with higher raw material costs, we will confirm the exact amount we can offer so everything is clear before shipping.

Standard Packaging and Private Label

For regular shipments, we usually pack goods in 1–5 kg aluminum foil bags, 10–20 kg cartons, or 10–30 kg fiber drums, depending on the item and order size.

If you’re planning to sell under your own brand, we also handle private labeling. We can help design and produce packaging with your logo or artwork so the products arrive ready for retail. Many customers find this saves them a lot of time compared with printing and repacking on their end.

Shipping Method

Orders under one metric ton are generally shipped through major express couriers such as DHL, FedEx, UPS or EMS. For larger quantities, we can arrange transport by sea or railway. The best method depends on your location and how quickly you need the goods, so we’ll help you choose the most practical option.

After Sale Services

Most of our products remain stable for up to two years, and we guarantee their quality within that period. If anything arrives below your expectations, our return process is straightforward. You can send back the portion in question, and we will refund the corresponding amount—no complicated procedures or hidden conditions.

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