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Copper Peptide (glycyl-L-histidyl-L-lysine-copper, GHK-Cu)

Product Name Copper Peptide
INCI Copper tripeptide-1
CAS No 89030-95-5/49557-75-7
MF C14H22N6O4Cu/C14H24N6O4
Specification 99%
Test Method HPLC
Certificates HACCP, FSSC22000, Kosher, Halal, FDA, SGS
Shelf Time 2 years
Package 25kg/Drum

product details

Description

Copper Peptide (glycyl-L-histidyl-L-lysine-copper, GHK-Cu) is a naturally occurring tripeptide complex with a molecular weight of 401.9 g/mol (C₁₄H₂₄CuN₆O₄). This sky-blue colored compound consists of three key components:

1. The peptide sequence Gly-His-Lys

2. Copper(II) ion in square planar coordination

3. Two water molecules completing the coordination sphere

Copper-Peptide-(glycyl-L-histidyl-L-lysine-copper,-GHK-Cu)-(1)

Production Methods

1. Chemical Synthesis (Primary Method):
Solid-phase peptide synthesis (SPPS) using Fmoc chemistry
Copper chelation under controlled pH (7.0-7.5)
Typical purity: ≥98% by HPLC
Yield: 70-85% after purification

2. Fermentation-Derived:
Recombinant E. coli expression systems
Lower yield but higher stereochemical purity
Requires additional copper-loading steps

Molecular Characteristics

Copper content: 15.8±0.5% (w/w)

UV-Vis spectrum: λmax 252 nm (peptide), 600 nm (d-d transition)

Stability constants: log K = 16.5 for Cu²⁺ binding

Isoelectric point: 6.8

Physicochemical Properties

Solubility Profile:
Water: ≥100 mg/mL (25°C)
Ethanol: <1 mg/mL
Propylene glycol: 15 mg/mL

Stability Parameters:
pH stability: 5.5-7.5 (optimal)
Thermal stability: Degrades above 80°C
Photostability: Sensitive to UV light

Technical Specifications (Cosmetic Grade)

Copper-Peptide-(glycyl-L-histidyl-L-lysine-copper,-GHK-Cu)-(3)

Appearance: Light blue powder

Purity: ≥95% (HPLC)

Heavy metals (excluding Cu): ≤10 ppm

Residual solvents: ≤50 ppm

Endotoxin: ≤10 EU/mg

Water content: ≤5%

Benefits

1. Formulation Stability: Maintains integrity in aqueous systems

2. Color Indicator: Visible blue hue aids in quality control

3. pH Adaptability: Stable in cosmetic pH ranges

4. Synergistic Potential: Enhances other active ingredient performance

Copper-Peptide-(glycyl-L-histidyl-L-lysine-copper,-GHK-Cu)-(2)

Applications

1. Advanced Skin Care:
Anti-aging serums and creams
Wound healing formulations
Collagen-boosting treatments

2. Hair Care Systems:
Hair growth stimulants
Scalp revitalization products
Anti-hair loss solutions

3. Medical Aesthetics:
Post-procedure recovery creams
Scar reduction therapies
Dermatological preparations

4. Specialty Cosmetics:
Eye contour treatments
Neck and décolletage creams
Luxury skincare lines

Product Processing

Standard and Certificates

All of our products are made in a GMP-compliant facility where every step of production is carefully managed. Over the years, our factory has passed several well-recognized audits, including HACCP, ISO22000 and ISO9001. The products also meet Kosher and Halal requirements, and we hold FDA registration as well. These certifications reflect the standards we follow rather than just labels we collect—they’re part of how we ensure consistency and safety in every batch.

Free Sample Available

If you’d like to get a feel for the product before placing an order, we can send you a free sample. In most cases, we provide around 10–20 grams so you can evaluate the quality yourself. For items with higher raw material costs, we will confirm the exact amount we can offer so everything is clear before shipping.

Standard Packaging and Private Label

For regular shipments, we usually pack goods in 1–5 kg aluminum foil bags, 10–20 kg cartons, or 10–30 kg fiber drums, depending on the item and order size.

If you’re planning to sell under your own brand, we also handle private labeling. We can help design and produce packaging with your logo or artwork so the products arrive ready for retail. Many customers find this saves them a lot of time compared with printing and repacking on their end.

Shipping Method

Orders under one metric ton are generally shipped through major express couriers such as DHL, FedEx, UPS or EMS. For larger quantities, we can arrange transport by sea or railway. The best method depends on your location and how quickly you need the goods, so we’ll help you choose the most practical option.

After Sale Services

Most of our products remain stable for up to two years, and we guarantee their quality within that period. If anything arrives below your expectations, our return process is straightforward. You can send back the portion in question, and we will refund the corresponding amount—no complicated procedures or hidden conditions.