Glycolic Acid (Alpha Hydroxyacetic Acid – AHA)
Introduction
Glycolic Acid (CAS No. 79-14-1; Molecular Formula: C₂H₄O₃; Molecular Weight: 76.05 g/mol) is the simplest and smallest molecule in the alpha-hydroxy acid (AHA) family. Its compact molecular structure allows rapid diffusion into the epidermis, making it highly effective for controlled exfoliation and dermal renewal.

It can be sourced naturally from sugarcane, sugar beets, and certain fruits, or produced synthetically via processes such as the catalytic oxidation of ethylene glycol or the reaction of formaldehyde with synthesis gas. High-purity grades (>99%) are obtained through precision crystallization and vacuum distillation, ensuring consistency for cosmetic and pharmaceutical applications.
Chemical & Physical Properties
|
Parameter |
Typical Value |
Significance |
|
Molecular Weight |
76.05 g/mol |
Enables high dermal penetration |
|
Melting Point |
75–80 °C |
Solid crystalline stability |
|
Boiling Point |
100–101 °C at 15 mmHg |
Low volatility under vacuum |
|
pKa |
3.83 |
Defines acidic strength for formulation pH control |
|
Specific Gravity (70% solution) |
1.27 g/cm³ |
High density aqueous solution |
|
Solubility |
Fully miscible in water, ethanol, acetone |
Broad formulation compatibility |
|
Purity Grades |
70% aqueous / ≥99% crystalline |
For cosmetic & technical applications |
Market Insights
High efficacy at low dosage – visible skin texture improvement at 5–10% concentration in topical formulas
Global regulatory acceptance – approved for cosmetic use in EU, US, and Asian markets within concentration guidelines
Growing demand – projected CAGR of 6–8% in cosmetic active ingredient segment over the next five years
Benefits
✓ Effective Exfoliation – Removes dead skin cells by dissolving intercellular bonds, improving smoothness and radiance.
✓ Skin Tone Correction – Helps reduce hyperpigmentation, sunspots, and uneven tone through enhanced cell turnover.

✓ Anti-Aging Support – Stimulates collagen synthesis and fibroblast activity, improving firmness and reducing fine lines.
✓ Acne & Pore Care – Clears clogged pores, reduces breakouts, and minimizes post-acne marks.
✓ Proven Efficacy – Clinical studies confirm increased epidermal turnover and improved hydration with consistent use.
Applications
Face & Body Care: Cleansers, toners, serums, masks, lotions for texture refinement and brightening
Professional Peels: Controlled concentration peels for acne scars, pigmentation, and photoaging
Acne Treatment: Formulations targeting pore cleansing and oil control
Brightening Solutions: Pads, essences, or creams to even skin tone
Industrial Uses: pH adjustment, cleaning formulations, organic synthesis intermediate
Product Processing












