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L-Glutathione (γ-L-Glutamyl-L-cysteinylglycine, GSH)

Product Name L-Glutathione
CAS No 70-18-8
MF C10H17N3O6S
MW 307.325
Specification 99%
Test Method HPLC/UV
Certificates HACCP, FSSC22000, Kosher, Halal, FDA, SGS
Shelf Time 2 years
Package 25kg/Drum

product details

Description (Data-Driven)

L-Glutathione (γ-L-Glutamyl-L-cysteinylglycine, GSH) is a tripeptide composed of glutamate, cysteine, and glycine, serving as the most abundant intracellular antioxidant in humans and many organisms48. It exists in two forms:

Reduced (GSH): The active antioxidant state (~90% in healthy cells)

Oxidized (GSSG): The dimerized, inactive form (~10%, recycled back to GSH via glutathione reductase)

Key Biochemical Properties

Molecular Formula: C₁₀H₁₇N₃O₆S

Molecular Weight: 307.32 g/mol

Solubility:
Water: Highly soluble (50 mg/mL at 25°C)
Ethanol: Slightly soluble
Insoluble in nonpolar solvents (e.g., ether, chloroform)

Natural Sources & Extraction

Plant Sources: Spinach (100–200 mg/100g), avocado (25–50 mg/100g), asparagus (15–30 mg/100g)8

Extraction Methods:
Cold-water extraction (preserves GSH integrity)
Enzymatic hydrolysis (improves yield from plant tissues)
Membrane filtration (removes heavy metals & impurities)

Biosynthetic Pathway

GSH synthesis occurs via two ATP-dependent enzymatic steps:

γ-Glutamylcysteine synthetase (GCL)

Km: 1.8 mM for glutamate

Inhibited by GSH (feedback regulation)

Glutathione synthetase (GS)

Km: 0.3 mM for γ-Glu-Cys

Requires Mg²⁺ as cofactor

Benefits

✔ Powerful Antioxidant – Neutralizes free radicals & oxidative stress

✔ Detoxification – Binds & eliminates heavy metals & toxins

✔ Skin Health – Reduces pigmentation & supports collagen synthesis

✔ Liver Protection – Enhances detox enzyme activity

✔ Immune Boost – Strengthens white blood cell function

Applications

Nutraceuticals: Capsules (100–500 mg/day), liposomal forms for better absorption

Cosmeceuticals: Anti-aging serums, skin-brightening creams

Functional Foods: Fortified beverages, detox shots

Medical Research: Investigated for neuroprotection, anti-cancer, and anti-aging effects

Product Processing

Standard and Certificates

All of our products are made in a GMP-compliant facility where every step of production is carefully managed. Over the years, our factory has passed several well-recognized audits, including HACCP, ISO22000 and ISO9001. The products also meet Kosher and Halal requirements, and we hold FDA registration as well. These certifications reflect the standards we follow rather than just labels we collect—they’re part of how we ensure consistency and safety in every batch.

Free Sample Available

If you’d like to get a feel for the product before placing an order, we can send you a free sample. In most cases, we provide around 10–20 grams so you can evaluate the quality yourself. For items with higher raw material costs, we will confirm the exact amount we can offer so everything is clear before shipping.

Standard Packaging and Private Label

For regular shipments, we usually pack goods in 1–5 kg aluminum foil bags, 10–20 kg cartons, or 10–30 kg fiber drums, depending on the item and order size.

If you’re planning to sell under your own brand, we also handle private labeling. We can help design and produce packaging with your logo or artwork so the products arrive ready for retail. Many customers find this saves them a lot of time compared with printing and repacking on their end.

Shipping Method

Orders under one metric ton are generally shipped through major express couriers such as DHL, FedEx, UPS or EMS. For larger quantities, we can arrange transport by sea or railway. The best method depends on your location and how quickly you need the goods, so we’ll help you choose the most practical option.

After Sale Services

Most of our products remain stable for up to two years, and we guarantee their quality within that period. If anything arrives below your expectations, our return process is straightforward. You can send back the portion in question, and we will refund the corresponding amount—no complicated procedures or hidden conditions.